A BSA complex with linoleic acid
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Contained In
44717BSA-Linoleate Reagent Set (1 mM)
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BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (1 mM)

Item No. 38649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Bovine Serum Albumin-LA
  • Bovine Serum Albumin-Linoleate
  • BSA-LA
  • BSA-9(Z),12(Z)-Octadecadienoic Acid
Source
Animal/Bovine
Formulation (Request formulation change)
1 mM linoleate:0.17 mM BSA in 150 mM sodium chloride
Origin
Animal/Bovine
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 ml

    $120

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    Product Description

    BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (1 mM) is composed of linoleic acid (Item No. 90150) and fatty acid-free bovine serum albumin (BSA) at an approximately 6:1 molar ratio of linoleate:BSA. It can be used for efficient fatty acid delivery to cells in culture as a source of essential nutrients to support cell growth in serum-free or reduced-serum media. It can also be used for the purpose of monitoring lipid metabolism and inflammatory signaling pathways, as linoleic acid is a precursor to arachidonic acid and downstream inflammatory lipid mediators.1,2,3,4,5 Cayman's BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (1 mM) is suitable for use in short-term cell culture applications (acute treatment to 18 hours); however, for long-term applications (25+ hours) the product should be filter-sterilized using a 0.2 µm filter and sterile receptacle, which will not affect its performance. For best results, it is recommended that this product be used in conjunction with Cayman's BSA Control for BSA-Fatty Acid Complexes (1 mM) (Item No. 34932), prepared with fatty acid-free BSA. A BSA-linoleate complex is also available as part of Cayman's BSA-Linoleate Reagent Set (1 mM) (Item No. 44717).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alsabeeh, N., Chausse, B., Kakimoto, P.A., et al. Cell culture models of fatty acid overload: Problems and solutions. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1863(2), 143-151 (2018).

    2. Menon, D., Salloum, D., Bernfeld, E., et al. Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid. The Journal of Biological Chemisty 292(15), 6303-6311 (2017).

    3. Wiesenfeld, P.W., Babu, U.S., and O'Donnell, M.W. Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 128(1), 123-134 (2001).

    4. Colquhoun, A., and Curi, R. Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. Biochem. Soc. Trans. 25(4), S681 (1997).

    5. Mukherjee, A., Adhikari, A., Das, P., et al. Loss of virulence in NAD(P)H cytochrome b5 oxidoreductase deficient Leishmania major. Biochem. Biophys. Res. Commun. 503(1), 371-377 (2018).

    Product Citations

    Abraham, E., Kostina, A., Volmert, B., et al. A retinoic acid: YAP1 signaling axis controls atrial lineage commitment. Cell Rep. 44(5), 115687 (2025).