A thioredoxin inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ferroptocide

Item No. 39005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3aS,4S,5R,7R,8S,8aS,9R)-octahydro-2,8a-dihydroxy-4,8,9-trimethyl-1-oxo-5-(2,3,5,8-tetrahydro-1,3-dioxo-2-phenyl-1H-[1,2,4]triazolo[1,2-a]pyridazin-6-yl)-1H-3a,8-propanoazulen-7-yl ester, 2-chloro-acetic acid
CAS Number
2505218-38-0
Molecular Formula
C30H36ClN3O7
Formula Weight
586.1
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(N1CC([C@H](C[C@@H](OC(CCl)=O)[C@]23C)[C@@H]([C@@]([C@]3(C([C@H]4O)=O)O)(C4)CC[C@H]2C)C)=CCN15)N(C6=CC=CC=C6)C5=O
InChi Code
InChI=1S/C30H36ClN3O7/c1-17-9-11-29-14-22(35)25(37)30(29,40)28(17,3)23(41-24(36)15-31)13-21(18(29)2)19-10-12-32-26(38)34(27(39)33(32)16-19)20-7-5-4-6-8-20/h4-8,10,17-18,21-23,35,40H,9,11-16H2,1-3H3/t17-,18+,21-,22+,23-,28+,29+,30-/m1/s1
InChi Key
LLYJISDUHFXOHK-GOCONZMPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $33

    Add

    5 mg

    $148

    Add

    10 mg

    $261

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Ferroptocide is an inhibitor of thioredoxin (Trx) and a derivative of pleuromutilin (Item No. 19452).1 It inhibits Trx activity in ES-2 ovarian cancer cells when used at a concentration of 20 µM and is cytotoxic to ES-2 cells (IC50 = 1.6 µM). Ferroptocide (5 µM) induces ferroptosis in ES-2 cells, an effect that can be blocked by the iron chelator deferoxamine (DFO; Item No. 14595), antioxidant Trolox (Item No. 10011659), or ferroptosis inhibitor ferrostatin-1 (Item No. 17729). It decreases tumor volume in a 4T1 murine mammary carcinoma model using immunocompetent but not immunodeficient mice when administered at 50 mg/kg twice per week.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Llabani, E., Hicklin, R.W., Lee, H.Y., et al. Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis. Nat. Chem. 11(6), 521-532 (2019).