An amine-terminated PAMAM dendrimer
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PAMAM Dendrimer G0.0 Amine (water solution)

Item No. 39053

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3′,3′′,3′′′-(1,2-ethanediyldinitrilo)tetrakis[N-(2-aminoethyl)-propanamide
CAS Number
155773-72-1
Synonyms
  • PAMAM G0.0
  • Polyamidoamine Dendrimer G0.0
Molecular Formula
C22H48N10O4
Formula Weight
516.7
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(NCCN)CCN(CCC(NCCN)=O)CCN(CCC(NCCN)=O)CCC(NCCN)=O
InChi Code
InChI=1S/C22H48N10O4/c23-5-9-27-19(33)1-13-31(14-2-20(34)28-10-6-24)17-18-32(15-3-21(35)29-11-7-25)16-4-22(36)30-12-8-26/h1-18,23-26H2,(H,27,33)(H,28,34)(H,29,35)(H,30,36)
InChi Key
SENLDUJVTGGYIH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 mg

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    Product Description

    PAMAM dendrimer G0.0 amine (PAMAM G0.0) is the polyamidoamine (PAMAM) core with amine termini on which other PAMAM dendrimers are synthesized.1 It is approximately 15 Å in diameter and has 4 surface groups. PAMAM G0.0 is an antagonist for the pore-forming channels anthrax toxin protective antigen 63 (PA63; IC50 = 231 nM) and C. botulinum C2 toxin subunit C2IIa (IC50 = 940 nM) in lipid membranes.2 It reduces C2 toxin-induced death in HeLa cells when used at concentrations of 10 and 20 µM. PAMAM G0.0 is a chelator of nickel.3 In complex with polysulfone membrane-bound chitosan, PAMAM G0.0 selectively captures and stores carbon dioxide (CO2) over nitrogen (N2) in a gas-feed system.4 PAMAM G0.0 has been used in the synthesis of PAMAM dendrimer G0.5 carboxylate (Item No. 39104) and PAMAM dendrimer G1.0 amine (Item No. 39054).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heiden, T.C., Dengler, E., Kao, W.J., et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol. Appl. Pharmacol. 225(1), 70-79 (2007).

    2. Förstner, P., Bayer, F., Kalu, N., et al. Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors. Biomacromolecules 15(7), 2461-2474 (2014).

    3. Sohail, I., Bhatti, I.A., Ashar, A., et al. Polyamidoamine (PAMAM) dendrimers synthesis, characterization and adsorptive removal of nickel ions from aqueous solution. J. Mater. Res. Technol. 9(1), 498-506 (2020).

    4. Duan, S., Kouketsu, T., Kazama, S., et al. Development of PAMAM dendrimer composite membranes for CO2 separation. J. Memb. Sci. 283(1-2), 2-6 (2006).