An amine-terminated PAMAM dendrimer
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PAMAM Dendrimer G4.0 Amine (water solution)

Item No. 39074

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
163442-67-9
Synonyms
  • PAMAM G4.0
  • Polyamidoamine Dendrimer G4.0
Molecular Formula
[NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
Formula Weight
14214.2
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 mg

    $263

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    1 g

    $500

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    Product Description

    PAMAM dendrimer G4.0 amine (PAMAM G4.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo.1,2 It is approximately 45 Å in diameter and has 64 surface groups.1 It inhibits fibril formation by α-synuclein in a cell-free assay when used at concentrations of 1 and 2 µM.3 PAMAM G4.0 is active against E. coli (IC50 = 3.8 µg/ml) and toxic to zebrafish embryos, inducing mortality at 120 hours post-fertilization when used at concentrations ranging from 0.5 to 20 µM.1,4 PAMAM G4.0 (100 and 300 mg/kg) in complex with the topoisomerase I inhibitor camptothecin (Item No. 11694) increases the oral bioavailability of camptothecin in mice without inducing gastrointestinal toxicity.5 PEG-modified PAMAM G4.0 in complex with folic acid (Item No. 20515), 5-fluorouracil (5-FU; Item No. 14416), and the imaging agent technetium-99m (PEG-PAMAM G4-FA-5FU-99mTc) localizes to the tumor, as well as the liver and spleen, in a 4T1 murine mammary tumor model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heiden, T.C., Dengler, E., Kao, W.J., et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol. Appl. Pharmacol. 225(1), 70-79 (2007).

    2. Narmani, A., Yavari, K., and Mohammadnejad, J. Imaging, biodistribution and in vitro study of smart 99mTc-PAMAM G4 dendrimer as novel nano-complex. Colloids Surf. B Biointerfaces 159, 232-240 (2017).

    3. Milowska, K., Malachowska, M., and Gabryelak, T. PAMAM G4 dendrimers affect the aggregation of α-synuclein. Int. J. Biol. Macromol. 48(5), 742-746 (2011).

    4. Wang, B., Navath, R.S., Menjoge, A.R., et al. Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers. Int. J. Pharm. 395(1-2), 298-308 (2010).

    5. Sadekar, S., Thiagarajan, G., Bartlett, K., et al. Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin. Int. J. Pharm. 456(1), 175-185 (2013).