A carboxylate-terminated PAMAM dendrimer
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PAMAM Dendrimer G4.5 Carboxylate (sodium salt) (water solution)

Item No. 39109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
202009-66-3
Synonyms
  • PAMAM G4.5 Carboxylate
  • Polyamidoamine Dendrimer G4.5 Carboxylate
Molecular Formula
[NH2(CH2)2NH2]:(G=4.5);dendri PAMAM(NHCH2CH2COONa)128
Formula Weight
26251.9
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $351

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    1 g

    $667

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    Product Description

    PAMAM dendrimer G4.5 carboxylate (PAMAM G4.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system.1 It is approximately 87.9 Å in diameter in water and has 96 surface groups.2 Unlike the amine-terminated PAMAM G5.0 (Item No. 39075), it does not rupture bilayer lipid membranes when used at a concentration of 50 µM.3 PAMAM G4.5 carboxylate disulfur-linked aggregates (10 µg/ml) encapsulating the phenol ferulic acid (Item No. 19871) and the mitotic inhibitor paclitaxel (Item No. 10461) induce apoptosis and decrease the mitochondrial membrane potential in multidrug-resistant KB-8-5 epidermal carcinoma cells.1 Complexes of PAMAM G4.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 620 nM).4 A fluorescently labeled form of PAMAM G4.5 carboxylate selectively accumulates in tumors and kidneys over liver, spleen, heart, and lungs in a 4T1 murine mammary carcinoma model.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anbazhagan, R., Muthusamy, G., Krishnamoorthi, R., et al. PAMAM G4.5 dendrimers for targeted delivery of ferulic acid and paclitaxel to overcome P-glycoprotein-mediated multidrug resistance. Biotechnol. Bioeng. 118(3), 1213-1223 (2021).

    2. Caminati, G., Turro, N.J., and Tomalia, D.A. Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants. J. Am. Chem. Soc. 112(23), 8515-8522 (1990).

    3. Shcharbin, D., Drapeza, A., Loban, V., et al. The breakdown of bilayer lipid membranes by dendrimers. Cell. Mol. Biol. Lett. 11(2), 242-248 (2006).

    4. Kirkpatrick, G.J., Plumb, J.A., Sutcliffe, O.B., et al. Evaluation of anionic half generation 3.5-6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin. J. Inorg. Biochem. 105(9), 1115-1122 (2011).

    5. Oddone, N., Lecot, N., Fernández, M., et al. In vitro and in vivo uptake studies of PAMAM G4.5 dendrimers in breast cancer. J. Nanobiotechnology 14(1), 45 (2016).