PAMAM Dendrimer G5.5 Carboxylate (sodium salt) (water solution)

PAMAM dendrimer G5.5 carboxylate (PAMAM G5.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro.¹ It is approximately 103.9 Å in diameter in water and has 192 surface groups.² Unlike PAMAM dendrimer G3.0 amine (Item No. 39073), PAMAM G5.5 carboxylate (100 µg/ml) does not induce cytotoxicity or autophagy in A549 cells.³ Bimetallic nanoparticles of PAMAM G5.5 carboxylate with gold and platinum scavenge DPPH (Item No. 14805) radicals in a cell-free assay.⁴ Complexes of PAMAM G5.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC₅₀ = 1.48 µM).¹

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1. Kirkpatrick, G.J., Plumb, J.A., Sutcliffe, O.B., et al. Evaluation of anionic half generation 3.5-6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin. J. Inorg. Biochem. 105(9), 1115-1122 (2011).

2. Caminati, G., Turro, N.J., and Tomalia, D.A. Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants. J. Am. Chem. Soc. 112(23), 8515-8522 (1990).

3. Li, C., Liu, H., Sun, Y., et al. PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. J. Mol. Cell Biol. 1(1), 37-45 (2009).

4. Endo, T., Fukunaga, T., Yoshimura, T., et al. Scavenging DPPH radicals catalyzed by binary noble metal–dendrimer nanocomposites. J. Colloid Interface Sci. 302(2), 516-521 (2006).