5-O-Methylvisammioside

5-O-Methylvisammioside is a chromone that has been found in S. diviaricata and has diverse biological activities.^1,2,3,4 It inhibits the protein-protein interaction between histone H3 and 14-3-3ε and phosphorylation of histone H3, as well as induces cell cycle arrest at the G₂/M phase, in HT-29 colon cancer cells when used at a concentration of 10 µM.¹ 5-O-Methylvisammioside (10-100 µM) inhibits histamine release induced by the mast cell degranulator compound 48/80 (Item No. 22173) in LAD 2 mast cells.² It reduces LPS-induced increases in nitric oxide (NO), malondialdehyde (MDA), and nuclear NF-κB levels in BV-2 microglia and decreases immobility time in the tail suspension and forced swim tests in mice.³ 5-O-Methylvisammioside (400 µg/kg) inhibits perivascular adventitia leukocyte infiltration and improves neurological deficits in a rat model of subarachnoid hemorrhage-induced vasospasm.⁴ It has been used as a quality control marker of S. diviaricata roots.⁵

WARNING This product is not for human or veterinary use.

1. Kang, J.-S., Chin, Y.-W., Lee, K., et al. Identification of 4'-O-β-D-glucosyl-5-O-methylvisamminol as a novel epigenetic suppressor of histone H3 phosphorylation at Ser¹⁰ and its interaction with 14-3-3ε. Bioorg. Med. Chem. Lett. 24(19), 4763-4767 (2014).

2. Jia, Q., Sun, W., Zhang, L., et al. Screening the anti-allergic components in Saposhnikoviae Radix using high-expression Mas-related G protein-coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry. J. Sep. Sci. 42(14), 2351-2359 (2019).

3. Sun, X., Zhang, T., Zhao, Y., et al. The protective effect of 5-O-methylvisammioside on LPS-induced depression in mice by inhibiting the over activation of BV-2 microglia through Nf-κB/IκB-α pathway. Phytomedicine 79:153348, (2020).

4. Chang, C.-Z., Wu, S.-C., Kwan, A.-L., et al. 4'-O-β-D-glucosyl-5-O-methylvisamminol, an active ingredient of Saposhnikovia divaricata, attenuates high-mobility group box 1 and subarachnoid hemorrhage-induced vasospasm in a rat model. Behav. Brain Funct. 11(1), 28 (2015).

5. Yang, J.-M., Jiang, H., Dai, H.-L., et al. Feeble antipyretic, analgesic, and anti-inflammatory activities were found with regular dose 4'-O-β-D-glucosyl-5-O-methylvisamminol, one of the conventional marker compounds for quality evaluation of Radix Saposhnikoviae. Pharmacogn. Mag. 13(49), 168-174 (2017).