Daminozide-d₄

Daminozide-d₄ is intended for use as an internal standard for the quantification of daminozide (Item No. 12033) by GC- or LC-MS. Daminozide is an inhibitor of the 2-oxoglutarate histone lysine demethylases KDM2A, PHF8, and KDM7A (IC₅₀s = 1.5, 0.55, and 2.1 µM, respectively) and a plant growth regulator.¹ It is selective for KDM2A, PHF8, and KDM7A over KDM3-6 (IC₅₀s = >100 µM for all), as well as the additional 2-oxoglutarate oxygenases FIH, EGLN1, and BBOX1 (IC₅₀s = >100 µM for all). It reduces peduncle and internodal elongation in C. officinalis when applied at the visible bud stage at concentrations of 1,500, 3,500, or 5,000 ppm.² Formulations containing daminozide have previously been used in agricultural applications to control plant growth and fruit size.

WARNING This product is not for human or veterinary use.

1. Rose, N.R., Woon, E.C.Y., Tumber, A., et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J. Med. Chem. 55(14), 6639-6643 (2012).

2. Armitage, A.M., Bergmann, B., and Bell, E.L. Effect of daminozide and light intensity on growth and flowering of calendula as a potted plant. HortScience 22(4), 611-612 (1987).