A phenolic acid with diverse biological activities
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Isomer(s)
35203Methyl 4-hydroxycinnamate
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4-Methoxycinnamic Acid

Item No. 39500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-methoxyphenyl)-2-propenoic acid
CAS Number
830-09-1
Synonyms
  • NSC 5303
  • NSC 623437
  • O-methyl-p-Coumaric Acid
  • p-Methoxycinnamic Acid
  • para-Methoxycinnamic Acid
Molecular Formula
C10H10O3
Formula Weight
178.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C=CC1=CC=C(C=C1)OC)O
InChi Code
InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)
InChi Key
AFDXODALSZRGIH-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $29

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    10 g

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    25 g

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    50 g

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    Cayman Chemical
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    Product Description

    4-Methoxycinnamic acid is a phenolic acid with diverse biological activities.1,2,3,4 It reduces A. fumigatus biofilm formation when used at concentrations ranging from 0.4 to 3.2 mM.1 In vivo, 4-methoxycinnamic acid (80 mg/kg) reduces the number of dysplastic aberrant crypt foci and dysplastic liver cells in a rat model of 1,2-dimethylhydrazine-induced colon carcinogenesis.2 It reverses MK-801-induced decreases in the preference ratio for the novel object in the novel object recognition test in mice.3 4-Methoxycinnamic acid (40 mg/kg) reduces plasma glucose concentrations in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Y., Yin, M., Gu, L., et al. The therapeutic role and mechanism of 4-methoxycinnamic acid in fungal keratitis. Int. Immunopharmacol. 116, 109782 (2023).

    2. Gunasekaran, S., Venkatachalam, K., Jeyavel, K., et al. Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes. Mol. Cell Biochem. 476(5), 2251-2252 (2021).

    3. Adisakwattana, S., Roengsamran, S., Hsu, W.H., et al. Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. Life Sci. 78(4), 406-412 (2005).

    4. Jeong, Y., Bae, H.J., Park, K., et al. 4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice. J. Ethnopharmacol. 285, 114864 (2022).