An internal standard for the quantification of acetamiprid
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Unlabeled Version(s)
24129Acetamiprid
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Acetamiprid-d3

Item No. 39565

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1E)-N-[(6-chloro-3-pyridinyl)methyl]-N′-cyano-N-(methyl-d3)-ethanimidamide
CAS Number
1353869-35-8
Molecular Formula
C10H8ClD3N4
Formula Weight
225.7
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
ClC1=CC=C(CN(C(C)=NC#N)C([2H])([2H])[2H])C=N1
InChi Code
InChI=1S/C10H11ClN4/c1-8(14-7-12)15(2)6-9-3-4-10(11)13-5-9/h3-5H,6H2,1-2H3/i2D3
InChi Key
WCXDHFDTOYPNIE-BMSJAHLVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Acetamiprid-d3 is intended for use as an internal standard for the quantification of acetamiprid (Item No. 24129) by GC- or LC-MS. Acetamiprid is a neonicotinoid insecticide that acts as an agonist of insect nicotinic acetylcholine receptors (nAChRs).1 It activates nAChRs containing N. lugens α1 and rat β2 subunits with an EC50 value of 67 µM in X. laevis oocytes. Acetamiprid administered to pregnant mice at a dose of 1 mg/kg leads to sexual and aggressive behaviors in adult male offspring while doses of 1 and 10 mg/kg decrease anxiety-like behavior of adult male offspring in the light-dark transition test.2 Formulations containing acetamiprid have been used to control sucking insects on crops and pets.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Z., Williamson, M.S., Lansdell, S.J., et al. A nicotinic acetylcholine receptor mutation (Y151S) causes reduced agonist potency to a range of neonicotinoid insecticides. J. Neurochem. 99(4), 1273-1281 (2006).

    2. Sano, K., Isobe, T., Yang, J., et al. In utero and lactational exposure to acetamiprid induces abnormalities in socio-sexual and anxiety-related behaviors of male mice. Front. Neurosci. 10, 228 (2016).