Acephate-d₃

Acephate-d3 is intended for use as an internal standard for the quantification of acephate (Item No. 24038) by GC- or LC-MS. Acephate is an organophosphate insecticide.¹ It inhibits acetylcholinesterase (AChE; K_i = 7 mM for the rat enzyme).² Acephate is lethal to houseflies (LD₅₀ = 1.8 mg/kg), mayflies, stoneflies, damselflies, and mosquitoes (LC₅₀s = 3.2, 37, 140, and 650 ppm, respectively).¹,² It is toxic to male and female rats (LD₅₀s = 945 and 866 mg/kg, respectively).¹ In vivo, acephate (140 mg/kg) also increases blood glucose, plasma corticosterone, hepatic glycogen levels, as well as decreases the activity of hepatic glucose-6-phosphate dehydrogenase (G6PDH) and adrenal cortisol levels, in rats.³ Formulations containing acephate have been used in the control of insects in agriculture and horticulture.

WARNING This product is not for human or veterinary use.

1. Rojakovick, A.S., and March, R.B. In vitro and in vivo inhibition of house fly acetylcholinesterase by the N-acetyl phosphoramidothioate orthene. J. Econ. Entomol. 65(5), 1505-1507 (1972).

2. Hussain, M.A., Mohamad, R.B., and Oloffs, P.C. Studies on the toxicity, metabolism, and anticholinesterase properties of acephate and methamidophos. J. Environ. Sci. Health B 20(1), 129-147 (1985).

3. Joshi, A.K.R., and Rajini, P.S. Reversible hyperglycemia in rats following acute exposure to acephate, an organophosphorus insecticide: Role of gluconeogenesis. Toxicology 257(1-2), 40-45 (2009).