A nucleoside derivative and PNP inhibitor
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Forodesine (hydrochloride)

Item No. 39609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, dihydrochloride
Molecular Formula
C11H14N4O4 • 2HCl
Formula Weight
339.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
230 nm
SMILES
O=C1C2=C(C([C@H]3[C@H](O)[C@H](O)[C@@H](CO)N3)=CN2)NC=N1.Cl.Cl
InChi Code
InChI=1S/C11H14N4O4.2ClH/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19;;/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19);2*1H/t5-,7+,9-,10+;;/m1../s1
InChi Key
BKBYUXDMYPGLTQ-PUSSMWDMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Forodesine is a purine nucleoside derivative and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively).1 It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = <0.1-0.38 µM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo; Item No. 9002864). Forodesine inhibits the proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells.2 In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bantia, S., Miller, P.J., Parker, C.D., et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (immucillin-H)-a novel potent and orally active immunosuppressive agent. Int. Immunopharmacol. 1(6), 1199-1210 (2001).

    2. Al-Kali, A., Gandhi, V., Ayoubi, M., et al. Forodesine: Review of preclinical and clinical data. Future Oncol. 6(8), 1211-1217 (2010).