An active metabolite of curcumin
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Parent Compound(s)
81025Curcumin 81025.1Curcumin (technical grade)
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Dihydrocurcumin

Item No. 39823

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-heptadien-3-one
CAS Number
76474-56-1
Synonyms
  • Letestuianin B
Molecular Formula
C21H22O6
Formula Weight
370.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: SolubleChloroform: SolubleDichloromethane: SolubleDMSO: SolubleEthyl Acetate: Soluble
SMILES
OC(C=C1)=C(OC)C=C1/C=C/C(O)=C/C(CCC2=CC(OC)=C(C=C2)O)=O
InChi Code
InChI=1S/C21H22O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3,5-7,9-13,22,24-25H,4,8H2,1-2H3/b7-3+,16-13-
InChi Key
BWHPKBOLJFNCPW-YJNULWIISA-N
Origin
Plant/Zingiber officinale Rose
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    Dihydrocurcumin is an active metabolite of curcumin (Item Nos. 81025 | 81025.1).1 It is formed from curcumin via reductases. It reduces triglyceride levels and increases glucose uptake in HepG2 and L-02 cellular models of steatosis induced by oleic acid (Item Nos. 90260 | 24659) when used at a concentration of 20 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pandey, A., Chaturvedi, M., Mishra, S., et al. Reductive metabolites of curcumin and their therapeutic effects. Heliyon 6(11), (2020).

    2. Yu, Q., Liu, Y., Wu, Y., et al. Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells. Biomed. Pharmacother. 103, 1327-1336 (2018).