A lignan with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Acanthoside B

Item No. 40280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dimethoxy-4-[(1S,3aR,4S,6aR)-tetrahydro-4-(4-hydroxy-3,5-dimethoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]phenyl-β-D-glucopyranoside
CAS Number
7374-79-0
Synonyms
  • Eleutheroside E1
Molecular Formula
C28H36O13
Formula Weight
580.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
[H][C@]12CO[C@H](C3=CC(OC)=C(O)C(OC)=C3)[C@@](CO[C@@H]2C4=CC(OC)=C(O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C(OC)=C4)1[H]
InChi Code
InChI=1S/C28H36O13/c1-34-16-5-12(6-17(35-2)21(16)30)25-14-10-39-26(15(14)11-38-25)13-7-18(36-3)27(19(8-13)37-4)41-28-24(33)23(32)22(31)20(9-29)40-28/h5-8,14-15,20,22-26,28-33H,9-11H2,1-4H3/t14-,15-,20+,22+,23-,24+,25+,26+,28-/m0/s1
InChi Key
WEKCEGQSIIQPAQ-IRBNZIFYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $50

    Add

    5 mg

    $211

    Add

    10 mg

    $323

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Acanthoside B is a lignan that has been found in P. villosa and has diverse biological activities.1,2,3 It scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (IC50s = 9.9 and 12.7 µM, respectively).1 Acanthoside B (20 µM) inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells.2 In vivo, acanthoside B (20 mg/kg) reverses scopolamine-induced memory impairment, reduces hippocampal malondialdehyde (MDA) levels, and increases hippocampal superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) levels in a mouse model of scopolamine-induced amnesia.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bai, M., Li, S.-F., Liu, S.-F., et al. Iridoid glycoside and lignans from a wild vegetable (Patrinia villosa Juss.) with antioxidant activity. J. Food Biochem. 42(3), e12521 (2018).

    2. Li, J., Guo, X., Luo, Z., et al. Chemical constituents from the flowers of Inula japonica and their anti-inflammatory activity. J. Ethnopharmacol. 318(Pt. B), 117052 (2024).

    3. Karthivashan, G., Kweon, M.-H., Park, S.-Y., et al. Cognitive-enhancing and ameliorative effects of acanthoside B in a scopolamine-induced amnesic mouse model through regulation of oxidative/inflammatory/cholinergic systems and activation of the TrkB/CREB/BDNF pathway. Food Chem. Toxicol. 129, 444-457 (2019).