A pyrimidine nucleoside and derivative of cytidine
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N4-Acetyl-2'-O-methylcytidine

Item No. 40285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-2′-O-methyl-cytidine
CAS Number
113886-71-8
Synonyms
  • ac4Cm
Molecular Formula
C12H17N3O6
Formula Weight
299.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: SolubleWater: Slightly soluble
SMILES
O=C(N=C(C=C1)NC(C)=O)N1[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OC
InChi Code
InChI=1S/C12H17N3O6/c1-6(17)13-8-3-4-15(12(19)14-8)11-10(20-2)9(18)7(5-16)21-11/h3-4,7,9-11,16,18H,5H2,1-2H3,(H,13,14,17,19)/t7-,9-,10-,11-/m1/s1
InChi Key
CYDFBLGNJUNSCC-QCNRFFRDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $62

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    1 g

    $117

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    5 g

    $370

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    Product Description

    N4-Acetyl-2'-O-methylcytidine (ac4Cm) is a pyrimidine nucleoside and a post-transcriptionally modified derivative of cytidine (Item No. 29602).1 ac4Cm has been found in the tRNA and 5S rRNA of Archaea thermophiles and increases RNA rigidity and stability through stronger complimentary base pairing with the purine nucleoside guanosine (Item No. 27702) compared to cytidine.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawai, G., Hashizume, T., Yasuda, M., et al. Conformational rigidity of N4-acetyl-2′-O-methylcytidine found in tRNA of extremely thermophilic archaebacteria (archaea). Nucleosides and Nucleotides 11(2-4), 759-777 (1992).

    2. Kowalak, J.A., Dalluge, J.J., McCloskey, J.A., et al. The role of posttranscriptional modification in stabilization of transfer RNA from hyperthermophiles. Biochemistry 33(25), 7869-7876 (1994).