A KAT6A and KAT7 inhibitor
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WM-3835

Item No. 40296

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-fluoro-5-methyl-[1,1′-biphenyl]-3-carboxylic acid, 2-[(3-hydroxyphenyl)sulfonyl]hydrazide
CAS Number
2229025-70-9
Molecular Formula
C20H17FN2O4S
Formula Weight
400.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(C1=CC(C2=CC=CC=C2)=CC(C)=C1F)NNS(=O)(C3=CC(O)=CC=C3)=O
InChi Code
InChI=1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26,27)17-9-5-8-16(24)12-17/h2-12,23-24H,1H3,(H,22,25)
InChi Key
KVJFJJXCBRSCDY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $157

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    25 mg

    $305

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    50 mg

    $566

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    Product Description

    WM-3835 is an inhibitor of lysine acetyltransferase 6A (KAT6A) and KAT7 (IC50s = 17 and 30 nM, respectively).1 It is selective for KAT6A and KAT7 over KAT5 (IC50 = 312 nM). WM-3835 (1 µM) reduces the viability of primary mouse leukemia stem cells (LSCs), MOLM-13 and OCI-AML-3 acute myeloid lymphoma (AML) cells, as well as decreases colony formation in patient-derived primary AML cells. It induces cell cycle arrest at the sub-G1 phase and apoptosis, as well as decreases the levels of mRNA encoding homeobox protein A7 (HOXA7), in MOLM-13 cells. In vivo, WM-3835 (5 mg/kg per day) reduces tumor volume, weight, and growth rate, as well as decreases the acetylation at lysine 14 on histone 3 (H3K14), H3K12, and H3K5 in tumor cell lysates, in a PPC-1 prostate cancer mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. MacPherson, L., Anokye, J., Yeung, M.M., et al. HBO1 is required for the maintenance of leukaemia stem cells. Nature 577(7789), 266-270 (2020).

    2. Mi, Y.-Y., Ji, Y., Zhang, L., et al. A first-in-class HBO1 inhibitor WM-3835 inhibits castration-resistant prostate cancer cell growth in vitro and in vivo. Cell Death Dis. 14(1), 67 (2023).