An alkaloid with diverse biological activities
Related Products
Active Metabolite(s)
36689Aposcopolamine 27052Scopine (hydrochloride)
Analytical Standard(s)
14108Scopolamine (hydrobromide)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Scopolamine

Item No. 40307

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αS-(hydroxymethyl)-benzeneacetic acid, (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester
CAS Number
51-34-3
Synonyms
  • Hyoscine
Molecular Formula
C17H21NO4
Formula Weight
303.4
Purity
≥98%
Formulation
A low-melting solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(O[C@H]1C[C@H](N2C)[C@@H]3O[C@@H]3[C@H]2C1)[C@H](CO)C4=CC=CC=C4
InChi Code
InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1
InChi Key
STECJAGHUSJQJN-FWXGHANASA-N
Origin
Plant/Datura
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $75

    Add

    100 mg

    $135

    Add

    250 mg

    $300

    Add

    500 mg

    $524

    Add
    Product Description

    Scopolamine is an alkaloid that has been found in D. stramonium and has diverse biological activities.1,2,3,4,5,6 It is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.19, 1.41, and 0.18 nM for the rat M1, M2, and M3 receptors, respectively).2 Scopolamine reduces acetylcholine-induced contractions in isolated guinea pig ileum (IC50 = 8.1 nM).3 It inhibits tremors induced by the mAChR agonist oxotremorine (Item No. 35707) in mice (ED50 = 0.23 mg/kg). Scopolamine increases fine motor activity counts and ambulatory activity in rats in a home-cage activity test (ED50 = 0.12 mg/kg for both).4 It has been used to induce learning deficiencies or amnesia in animal models.5,6 Formulations containing scopolamine have been used in the treatment of motion sickness and postoperative nausea and vomiting. This product is also available as an analytical reference standard (Item No. 14108).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, L., Gu, R., Tang, L., et al. Important poisonous plants in Tibetan ethnomedicine. Toxins (Basel) 7(1), 138-155 (2015).

    2. Lazareno, S., Buckley, N.J., and Roberts, F.F. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cell. Mol. Pharmacol. 38(6), 805-815 (1990).

    3. Fjalland, B., Christensen, A.V., and Hyttel, J. Peripheral and central muscarinic receptor affinity of psychotropic drugs. Naunyn. Schmiedebergs. Arch. Pharmacol. 301(1), 5-9 (1977).

    4. Sipos, M.L., Burchnell, V., and Galbicka, G. Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in rats. Psychopharmacology 147(3), 250-256 (1999).

    5. Bratt, A.M., Kelly, M.E., Domeney, A.M., et al. Acute and chronic arecoline: Effects on a scopolamine-induced deficit in complex maze learning. Pharmacol. Biochem. Behav. 53(3), 713-721 (1996).

    6. Ano, Y., Kutsukake, T., Sasaki, T., et al. Identification of a novel peptide from β-casein that enhances spatial and object recognition memory in mice. J. Agric. Food Chem. 67(29), 8160-8167 (2019).