An internal standard for the quantification of doxylamine
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Doxylamine-d5 (succinate)

Item No. 40674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, compd. with N,N-dimethyl-2-[1-phenyl-d5-1-(2-pyridinyl)ethoxy]ethanamine
CAS Number
1216840-94-6
Molecular Formula
C17H17D5N2O • C4H6O4
Formula Weight
393.5
Purity
≥95%
Formulation
A solid
SMILES
OC(CCC(O)=O)=O.CN(C)CCOC(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])(C2=CC=CC=N2)C
InChi Code
InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)/i4D,5D,6D,9D,10D;
InChi Key
KBAUFVUYFNWQFM-NBTFKYQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $659

    Add
    Product Description

    Doxylamine-d5 is intended for use as an internal standard for the quantification of doxylamine by GC- or LC-MS. Doxylamine is an antihistamine.1,2 It selectively inhibits contractions induced by histamine (Item No. 33828) over acetylcholine (ACh; Item No. 23829) in isolated guinea pig ileum (IC50s = 0.01 and 0.58 µg/ml, respectively).3 Doxylamine (2-4 mg/kg) protects rabbits against anaphylaxis induced by beef serum antigen.2 It reduces ethanol-induced deficits in behavior performance in rats when administered at a dose of 60 mg/kg.4 Formulations containing doxylamine have been used in the treatment of nausea and vomiting in pregnant women and insomnia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brown, B.B., Werner, H.W., and Peters, E.L. The pharmacologic properties of 2-[α-(2-dimethylaminoethoxy)-α-methylbenzyl]-pyridine succinate, a new antihistaminic agent. J. Lab. Clin. Med. 33(3), 325-331 (1948).

    2. Brown, B.B., and Werner, H.W. The effects of decapryn succinate, a new antihistamine agent, in some natural and acquired hypersensitivities in animals; 2-[α-dimethylaminoethoxy)-α-methyl-benzyl] pyridine succinate. Ann. Allergy 6(2), 122-130 (1948).

    3. Werle, E., and Lorenz, W. Bradykinin and Related Kinins Cardiovascular, Biochemical, and Neural Actions. Advances in Experimental Medicine and Biology 8, (1970).

    4. Allen, L.E., Ferguson, H.C., and McKinney, G.R. A survey of selected drugs on behavioral performance in ethanol-treated rats. Eur. J. Pharmacol. 15(3), 371-374 (1971).