An inhibitor of Kv1.3 and Kv1.4
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CP 339,818 (hydrochloride)

Item No. 40766

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine, monohydrochloride
CAS Number
478341-55-8
Molecular Formula
C21H24N2 • HCl
Formula Weight
340.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCCN=C1C=CN(CC2=CC=CC=C2)C3=C1C=CC=C3.Cl
InChi Code
InChI=1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H
InChi Key
JIRISCAPZWLWCG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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Download most recent Certificate of Analysis for this product

    5 mg

    $58

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    10 mg

    $109

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    25 mg

    $258

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    50 mg

    $458

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    Product Description

    CP 339,818 is an inhibitor of voltage-gated potassium channel Kv1.3 and Kv1.4 (IC50s = 0.23 and 0.3 µM, respectively).1 It is selective for these channels over Kv1.1, Kv1.2, Kv1.5, and Kv1.6 channels (IC50s = 62, 14, 19, and 20 µM, respectively), as well as Kv3.1, Kv3.2, Kv3.4, and Kv4.2 channels (IC50s = 17, 10, 36, and >10 µM, respectively). CP 339,818 inhibits thymidine incorporation, a marker of T cell activation, induced by an anti-CD3 antibody or a combination of ionomycin (Item Nos. 10004974 | 11932) and phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in isolated human peripheral blood T cells (IC50s = 4.7 and 5.2 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nguyen, A., Kath, J.C., Hanson, D.C., et al. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol. Pharmacol. 50(6), 1672-1679 (1996).