A GCGR antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LGD 6972 (ammonium salt)

Item No. 40961

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[(2R)-2-[4′-(1,1-dimethylethyl)[1,1′-biphenyl]-4-yl]-3-oxo-3-[(2′,4′,6′-trimethyl[1,1′-biphenyl]-4-yl)amino]propyl]benzoyl]amino]-ethanesulfonic acid, monoammonium salt
Molecular Formula
C43H45N2O5S • NH4
Formula Weight
719.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=C(C2=CC=C(C=C2)NC([C@@H](C3=CC=C(C4=CC=C(C=C4)C(C)(C)C)C=C3)CC5=CC=C(C=C5)C(NCCS(=O)([O-])=O)=O)=O)C(C)=CC(C)=C1.[NH4+]
InChi Code
InChI=1S/C43H46N2O5S.H3N/c1-28-25-29(2)40(30(3)26-28)35-17-21-38(22-18-35)45-42(47)39(27-31-7-9-36(10-8-31)41(46)44-23-24-51(48,49)50)34-13-11-32(12-14-34)33-15-19-37(20-16-33)43(4,5)6;/h7-22,25-26,39H,23-24,27H2,1-6H3,(H,44,46)(H,45,47)(H,48,49,50);1H3/t39-;/m1./s1
InChi Key
VZJMFAKZCPXIGY-DRRLCDGFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $53

    Add

    5 mg

    $225

    Add

    10 mg

    $370

    Add

    25 mg

    $594

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    LGD 6972 is a glucagon receptor (GCGR) antagonist.1 In vivo, LGD 6972 reduces glucagon-induced hyperglycemia in wild-type mice and reduces blood glucose levels in mouse models of diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vajda, E.G., Logan, D., Lasseter, K., et al. Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus. Diabetes Obes. Metab. 19(1), 24-32 (2017).