An active metabolite of enzalutamide
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Parent Compound(s)
11596Enzalutamide
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N-desmethyl Enzalutamide

Item No. 41025

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-benzamide
CAS Number
1242137-16-1
Synonyms
  • N-desmethyl MDV 3100
Molecular Formula
C20H14F4N4O2S
Formula Weight
450.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
FC1=CC(N(C(N2C3=CC=C(C#N)C(C(F)(F)F)=C3)=S)C(C)(C)C2=O)=CC=C1C(N)=O
InChi Code
InChI=1S/C20H14F4N4O2S/c1-19(2)17(30)27(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)28(19)12-5-6-13(16(26)29)15(21)8-12/h3-8H,1-2H3,(H2,26,29)
InChi Key
JSFOGZGIBIQRPU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $98

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    10 mg

    $148

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    50 mg

    $588

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    100 mg

    $1,077

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    Product Description

    N-desmethyl Enzalutamide is an active metabolite of the androgen receptor antagonist enzalutamide (Item No. 11596).1 It is formed from enzalutamide by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gibbons, J.A., Ouatas, T., Krauwinkel, W., et al. Clinical pharmacokinetic studies of enzalutamide. Clin. Pharmacokinet. 54(10), 1043-1055 (2015).

    2. Gibbons, J.A., de Vries, M., Krauwinkel, W., et al. Pharmacokinetic drug interaction studies with enzalutamide. Clin. Pharmacokinet. 54(10), 1057-1069 (2015).