An Mps1 inhibitor
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Mps1-IN-3

Item No. 41029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[3-methoxy-4-[[6-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-9H-purin-2-yl]amino]phenyl]-4-piperidinol
CAS Number
1609584-72-6
Synonyms
  • Monopolar Spindle1-IN-3
  • Monopolar Spindle 1 Inhibitor 3
  • Mps1 Inhibitor 3
Molecular Formula
C26H31N7O4S
Formula Weight
537.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CC(S(C1=C(C=CC=C1)NC2=NC(NC(C(OC)=C3)=CC=C3N4CCC(CC4)O)=NC5=C2NC=N5)(=O)=O)C
InChi Code
InChI=1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32)
InChi Key
OFRMASLPWOMYHN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Mps1-IN-3 is an inhibitor of monopolar spindle 1 (Mps1; IC50 = 50 nM).1 It inhibits the proliferation of U251 glioblastoma cells (IC50 = ~5 µM). Mps1-IN-3 (2 µM) prevents checkpoint-mediated mitotic arrest induced by nocodazole (Item No. 13857) in U2OS osteosarcoma cells and, when used at a concentration of 5 µM in combination with the antimitotic agents vincristine (Item No. 11764) or paclitaxel (Item No. 10461), induces nuclear aberrancies and chromosome missegregation defects in U251-FM-H2B-GFP cells, which express firefly luciferase, mCherry, and a histone H2B-GFP fusion reporter. It sensitizes U251-FM cells to vincristine and increases survival in an orthotopic mouse model of glioblastoma when administered at a dose of 2 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tannous, B.A., Kerami, M., Van der Stoop, P.M., et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J. Natl. Cancer Inst. 105(17), 1322-1331 (2013).