A chemical probe for MLLT1 and MLLT3
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PFI-6

Item No. 41162

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-2,3-dihydro-1H-inden-1-yl]-5-[4-[(dimethylamino)carbonyl]-3-hydroxyphenyl]-3-isoxazolecarboxamide
CAS Number
2675452-91-0
Molecular Formula
C22H21N3O4
Formula Weight
391.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/mlMethanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(N[C@@H]1CCC2=CC=CC=C21)C3=NOC(C4=CC(O)=C(C(N(C)C)=O)C=C4)=C3
InChi Code
InChI=1S/C22H21N3O4/c1-25(2)22(28)16-9-7-14(11-19(16)26)20-12-18(24-29-20)21(27)23-17-10-8-13-5-3-4-6-15(13)17/h3-7,9,11-12,17,26H,8,10H2,1-2H3,(H,23,27)/t17-/m1/s1
InChi Key
IXWUILRSNIQHDM-QGZVFWFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

    $186

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    Product Description

    PFI-6 is a chemical probe for the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 140 and 160 nM, respectively).1 It is selective for MLLT1 and MLLT3 over YEATS domain-containing 2 (YEATS2) and YEATS4 (IC50s = >30,000 nM for both). See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raux, B., Buchan, K.A., Bennett, J., et al. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg. Med. Chem. Lett. 98, 129546 (2024).