A lipid prodrug form of dexamethasone
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LD003

Item No. 41278

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β,16α)-9-fluoro-11,17-dihydroxy-16-methyl-21-[4-[(9Z,12Z)-9,12-octadecadien-1-yloxy]-1,4-dioxobutoxy]-pregna-1,4-diene-3,20-dione
CAS Number
2102449-40-9
Molecular Formula
C44H65FO8
Formula Weight
741.0
Purity
≥98%
Formulation
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
F[C@@]12[C@](CCC([C@@]2(C=C3)C)=CC3=O)([H])[C@@]4([H])[C@@]([C@](C(COC(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)=O)=O)(O)[C@@H](C4)C)(C[C@@H]1O)C
InChi Code
InChI=1S/C44H65FO8/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-27-52-39(49)23-24-40(50)53-31-38(48)44(51)32(2)28-36-35-22-21-33-29-34(46)25-26-41(33,3)43(35,45)37(47)30-42(36,44)4/h9-10,12-13,25-26,29,32,35-37,47,51H,5-8,11,14-24,27-28,30-31H2,1-4H3/b10-9-,13-12-/t32-,35+,36+,37+,41+,42+,43+,44+/m1/s1
InChi Key
BSDBWIPACPNDCK-YVLPIOENSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $149

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    10 mg

    $283

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    25 mg

    $669

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    Cayman Chemical
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    Product Description

    LD003 is a lipid prodrug form of the synthetic glucocorticoid dexamethasone (Item No. 11015) that has been used in the formation of lipid nanoparticles (LNPs) for siRNA and mRNA delivery in vivo.1 LNPs containing LD003 and encapsulating cytosine-guanine-containing oligodeoxynucleotide (CpG) reduce the blood levels of Il-10, chemokine (C-X-C motif) ligand 1 (CXCL1), TNF-α, IL-1β, and IL-6 in mice. LNPs containing LD003 and encapsulating siRNA targeting mouse coagulation Factor VII (FVII) decrease injection site immune infiltration and hepatic levels of FVII in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wolfman, N.M., McPherron, A.C., Pappano, W.N., et al. Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases. Proc. Natl. Acad. Sci. USA 100(26), 15842-15846 (2003).