A VEGFR2 antagonist
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AG-13958

Item No. 41352

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
CAS Number
319460-94-1
Molecular Formula
C26H22FN7O
Formula Weight
467.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC(C)=NN1C)NC(C=C2NC3=CC=C4C(/C=C/C5=CC=CC=N5)=NNC4=C3)=C(C=C2)F
InChi Code
InChI=1S/C26H22FN7O/c1-16-13-25(34(2)33-16)26(35)30-24-15-19(7-10-21(24)27)29-18-6-9-20-22(31-32-23(20)14-18)11-8-17-5-3-4-12-28-17/h3-15,29H,1-2H3,(H,30,35)(H,31,32)/b11-8+
InChi Key
JXSVVZKPEDIRTN-DHZHZOJOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $71

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    5 mg

    $335

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    10 mg

    $564

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    25 mg

    $935

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    Product Description

    AG-13958 is an antagonist of VEGFR2 (Ki = 0.3 nM).1 It inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = 0.31 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Solowiej, J., Chen, J.H., Zou, H.Y., et al. Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain. ACS Chem. Biol. 8(5), 978-986 (2013).