A Bcr-AblT315I inhibitor
Related Products
Isomer(s)
17667WS3
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BBT594

Item No. 41359

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[6-(acetylamino)-4-pyrimidinyl]oxy]-2,3-dihydro-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-1H-indole-1-carboxamide
CAS Number
882405-89-2
Synonyms
  • NVP-BBT594
Molecular Formula
C28H30F3N7O3
Formula Weight
569.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C)NC1=CC(OC2=CC=C3C(CCN3C(NC(C=C4C(F)(F)F)=CC=C4CN5CCN(CC5)C)=O)=C2)=NC=N1
InChi Code
InChI=1S/C28H30F3N7O3/c1-18(39)34-25-15-26(33-17-32-25)41-22-5-6-24-19(13-22)7-8-38(24)27(40)35-21-4-3-20(23(14-21)28(29,30)31)16-37-11-9-36(2)10-12-37/h3-6,13-15,17H,7-12,16H2,1-2H3,(H,35,40)(H,32,33,34,39)
InChi Key
VQLNKQZLPGLOSI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $54

    Add

    10 mg

    $103

    Add

    25 mg

    $244

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    BBT594 is an inhibitor of Bcr-AblT315I (IC50 = 44 nM), a form of the Bcr-Abl fusion protein containing a tyrosine-to-isoleucine substitution at position 315.1 It decreases proliferation in mouse Ba/F3 hematopoietic cells expressing Bcr-AblT315I (GI50 = 117 nM). BBT594 (1 or 5 µM) also inhibits phosphorylation of Jak2 and Stat5 in Ba/F3 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manley, P.W., Brüggen, J., Floersheimer, A., et al. Rational design of T3151 BCR-abl inhibitors for the treatment of drug-resistant chronic myelogenous leukemia (CML): BGG463. Med. Chem. 62(7/8), 579 (2008).

    2. Andraos, R., Qian, Z., Bonenfant, D., et al. Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent. Cancer Discov. 2(6), 512-523 (2012).