An HDAC11 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SIS17

Item No. 41360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-thiophenecarboxylic acid, 2-hexadecylhydrazide
CAS Number
2374313-54-7
Molecular Formula
C21H38N2OS
Formula Weight
366.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC
InChi Code
InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)
InChi Key
HSHXDCVZWHOWCS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $39

    Add

    10 mg

    $74

    Add

    25 mg

    $174

    Add

    50 mg

    $308

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    SIS17 is an inhibitor of histone deacetylase 11 (HDAC11; IC50 = 0.83 µM).1 It is selective for HDAC11 over HDAC1, -4, and -8 (IC50s = >100 µM for all) and sirtuin 1 (SIRT1), -2, -3, and -6 (IC50s = >100 µM for all). SIS17 (50 µM) increases fatty acylation of serine hydroxymethyltransferase 2 (SHMT2) in MCF-7 cells. It decreases the viability of K562 cells and enhances reductions in cell viability induced by oxaliplatin (Item No. 13106) in the same cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Son, S.I., Cao, J., Zhu, C.-L., et al. Activity-guided design of HDAC11-specific inhibitors. ACS Chem. Biol. 14(7), 1393-1397 (2019).

    2. Li, R., Wu, X., Zhao, P., et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. The FASEB Journal 36(7), e22326 (2022).