An MC4R antagonist
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SNT-207707 (hydrochloride)

Item No. 41524

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-imidazo[1,2-a]pyridine-6-carboxamide, monohydrochloride
CAS Number
1064662-40-3
Molecular Formula
C32H43N5O • HCl
Formula Weight
550.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CN2C(CCCN3CCCC3)=C(C(C=C4)=CC=C4C#N)N=C2C=C1)N(CCC(C)C)CCC(C)C.Cl
InChi Code
InChI=1S/C32H43N5O.ClH/c1-24(2)15-20-36(21-16-25(3)4)32(38)28-13-14-30-34-31(27-11-9-26(22-33)10-12-27)29(37(30)23-28)8-7-19-35-17-5-6-18-35;/h9-14,23-25H,5-8,15-21H2,1-4H3;1H
InChi Key
FBNJDWPWZNPVSC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $80

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    1 mg

    $127

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SNT-207707 is a melanocortin receptor 4 (MC4R) antagonist (IC50 = 5 nM).1 It increases food intake in mice when administered at a dose of 20 mg/kg. SNT-207707 (30 mg/kg per day) inhibits tumor-induced weight loss without inhibiting tumor growth in a C26 murine colon carcinoma model of tumor-induced cachexia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weyermann, P., Dallmann, R., Magyar, J., et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One 4(3), e4774 (2009).