Host: Insect cells • AA: 1-599 (full length) • Tag: N-terminal His and GST • MW: 94 kDa
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IGF2BP2 Long Isoform (human, recombinant)

Item No. 41533

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • IGF2 mRNA-binding Protein 2
  • Insulin-like Growth Factor 2 mRNA-binding Protein 2
  • IMP-2
  • VICKZ2
Purity
≥76% as estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Recombinant human N-terminal His-and GST-tagged IGF2BP2 long isoform expressed in insect cells
Amino Acids
1-599
MW
94 kDa
Formulation (Request formulation change)
Lyophilized from sterile 50 mM Tris, pH 8.0, 500 mM sodium chloride, 0.5 mM PMSF, and 5 mM reduced glutathione
UniProt Accession №
Q9Y6M1
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $328

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    Cayman Chemical
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    Product Description

    Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is an RNA-binding protein (RBP) and a member of the zipcode-binding protein (ZBP) family.1 It is composed of two N-terminal RNA recognition motifs (RRMs) and four C-terminal heterogeneous nuclear ribonucleoprotein (hnRNP) K-homology (KH) domains. IGF2BP2 is ubiquitously expressed during development and localizes to the cytoplasm.1,2 It exists as three isoforms: p58, which lacks an RRM motif, p62, which has a shortened linker region between KH2 and KH3, and the full-length isoform, p66.3 IGF2BP2 is involved in RNA processing through N6-methyladenosine (m6A) recognition, metabolism, neurogenesis, and embryonic development and interacts with several target transcripts, including IGF2, LAMB2, TRIM54, EIF4A1, and NTN4, as well as some mitochondrial genes.1,4,5 IGF2BP2 promotes or inhibits invasion and migration of cancer cells in vitro in a context-dependent manner.4,5 SNPs in IGF2BP2 are associated with an increased risk of type 2 diabetes.6 Cayman’s IGF2BP2 long isoform (human, recombinant) protein consists of 836 amino acids and has a calculated molecular weight of 94 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular weight of the protein is 90 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Du, Q.-Y., Zhu, Z.-M., and Pei, D.-S. The biological function of IGF2BPs and their role in tumorigenesis. Invest. New Drugs 39(6), 1682-1693 (2021).

    2. Zhang, Y., Xu, S., Xu, G., et al. Dynamic expression of m6A regulators during multiple human tissue development and cancers. Front. Cell Dev. Biol. 8, 629030 (2021).

    3. Le, H.T.T., Sorrell, A.M., and Siddle, K. Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation. PLoS One 7(3), e33140 (2012).

    4. Li, Y., Xiao, Z., Wang, Y., et al. The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation. Cancer Cell Int. 24(1), 162 (2024).

    5. Wang, G., Zhuang, T., Zhen, F., et al. IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting netrin-4 in an m6A-dependent manner. Mol. Carcinog. 63(8), 1572-1587 (2024).

    6. Dai, N. The diverse functions of IMP2/IGF2BP2 in metabolism. Trends in Endocrinol. Metab. 31(9), 679-679 (2020).