An adenosine A3 receptor antagonist
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DPTN (hydrochloride)

Item No. 41540

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(3,5-dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-3-pyridinecarboxamide, dihydrochloride
CAS Number
325767-87-1
Molecular Formula
C22H18N4OS • 2HCl
Formula Weight
459.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(C1=CN=CC=C1)NC2=NC(C3=CC(C)=CC(C)=C3)=C(C4=CC=NC=C4)S2.Cl.Cl
InChi Code
InChI=1S/C22H18N4OS.2ClH/c1-14-10-15(2)12-18(11-14)19-20(16-5-8-23-9-6-16)28-22(25-19)26-21(27)17-4-3-7-24-13-17;;/h3-13H,1-2H3,(H,25,26,27);2*1H
InChi Key
GTWKWBXTCBUKTR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

    $186

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    25 mg

    $416

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    50 mg

    $735

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    Product Description

    DPTN is an adenosine A3 receptor antagonist (Ki = 0.36 nM for the human receptor).1 It is selective for the adenosine A3 receptor over the adenosine A1 and A2A receptors (Kis = >666 and >826 nM, respectively). DPTN (10 mg/kg) prevents dye leakage in a rat model of plasma extravasation induced by the adenosine A3 receptor agonist IB-MECA (piclidenoson; Item No. 28445). It, alone and in combination with the synthetic glucocorticoid dexamethasone (Item No. 11015), inhibits airway hypersensitivity to acetylcholine in a rat model of allergen-induced asthma stimulated by ovalbumin inhalation when administered at a dose of 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miwatashi, S., Arikawa, Y., Matsumoto, T., et al. Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists. Chem. Pharm. Bull. 56(8), 1126-1137 (2008).