A peptide fragment of ACTH and an MC2R antagonist
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ACTH (11-24) (human, mouse, rat, porcine, bovine, ovine) (acetate)

Item No. 41559

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α11-24-corticotropin, acetate
Synonyms
  • α11-24-ACTH
  • Adrenocorticotropic Hormone (11-24)
  • Corticotropin (11-24)
Molecular Formula
C77H134N24O16 • XC2H4O2
Formula Weight
1652.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
KPVGKKRRPVKVYP-OH
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(O[H])C=C3)C(N4CCC[C@H]4C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN[H])N[H].CC(O)=O
InChi Code
InChI=1S/C77H134N24O16.C2H4O2/c1-44(2)60(97-67(108)56-26-17-39-99(56)72(113)49(82)20-7-11-33-78)69(110)89-43-59(103)90-50(21-8-12-34-79)63(104)91-51(22-9-13-35-80)64(105)92-53(24-15-37-87-76(83)84)65(106)94-54(25-16-38-88-77(85)86)73(114)100-40-18-27-57(100)68(109)98-62(46(5)6)70(111)93-52(23-10-14-36-81)66(107)96-61(45(3)4)71(112)95-55(42-47-29-31-48(102)32-30-47)74(115)101-41-19-28-58(101)75(116)117;1-2(3)4/h29-32,44-46,49-58,60-62,102H,7-28,33-43,78-82H2,1-6H3,(H,89,110)(H,90,103)(H,91,104)(H,92,105)(H,93,111)(H,94,106)(H,95,112)(H,96,107)(H,97,108)(H,98,109)(H,116,117)(H4,83,84,87)(H4,85,86,88);1H3,(H,3,4)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,60-,61-,62-;/m0./s1
InChi Key
FCUKBHOCSHSSNE-WKYQKWCMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Adrenocorticotropic hormone (ACTH) (11-24) is a peptide fragment of ACTH (Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response, and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor (IC50 = ~1 nM in HeLa cells expressing the mouse receptor).1,2 It induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 µM, respectively.3 Unlike ACTH (4-11) (Item No. 27430), ACTH (11-24) does not induce differentiation of primary mouse melanocytes.4 In vivo, ACTH (11-24) (1.69 µg/animal, i.c.v.) inhibits ACTH-induced stretching, yawning, and penile erections in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).

    2. Kapas, S., Cammas, F.M., Hinson, J.P., et al. Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137(8), 3291-3294 (1996).

    3. Szalay, K.S., De Wied, D., and Stark, E. Effects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cells. J. Steroid Biochem. 32(2), 259-262 (1989).

    4. Hirobe, T., and Hiroyuki, A. ACTH4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J. Exp. Zool. 286(6), 632-640 (2000).

    5. Genedani, S., and Bernardi, M. ACTH-(11-24) antagonizes ACTH-(1-24)-induced behavioral syndrome. Neuropeptides 26(4), 241-244 (1994).