A peptide nAChR antagonist
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RVG Peptide (trifluoroacetate salt)

Item No. 41606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-threonyl-L-isoleucyl-L-tryptophyl-L-methionyl-L-prolyl-L-α-glutamyl-L-asparaginyl-L-prolyl-L-arginyl-L-prolylglycyl-L-threonyl-L-prolyl-L-cysteinyl-L-α-aspartyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-arginylglycyl-L-lysyl-L-arginyl-L-alanyl-L-seryl-L-asparaginyl-glycine, trifluoroacetate salt
Synonyms
  • Rabies Virus Glycoprotein
  • Rabies Virus Glycoprotein 29
  • RABV-G
  • RVG29
Molecular Formula
C141H217N43O43S2 • XCF3COOH
Formula Weight
3266.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
YTIWMPENPRPGTPCDIFTNSRGKRASNG-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C(N[C@]([C@H](O[H])C)([H])C(N[C@@](C(N[C@@H](CC1=CN([H])C2=C1C=CC=C2)C(N[C@@H](CCSC)C(N3CCC[C@H]3C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N[H])=O)C(N4CCC[C@H]4C(N[C@@H](CCC/N=C(N[H])/N)C(N5CCC[C@H]5C(NCC(N[C@]([C@H](O[H])C)([H])C(N6CCC[C@H]6C(N[C@@H](CS[H])C(N[C@@H](CC(O)=O)C(N[C@@](C(N[C@H](C(N[C@]([C@H](O[H])C)([H])C(N[C@@H](CC(N[H])=O)C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@@H](CC(N[H])=O)C(NCC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC8=CC=C(O[H])C=C8)N[H].FC(F)(C(O)=O)F
InChi Code
InChI=1S/C141H217N43O43S2.C2HF3O2/c1-10-68(3)108(131(220)169-87(55-74-26-13-12-14-27-74)122(211)180-110(71(6)187)133(222)171-90(58-101(145)192)121(210)174-94(66-186)124(213)162-81(31-19-46-153-139(147)148)115(204)157-62-103(194)161-82(30-17-18-45-142)118(207)163-83(32-20-47-154-140(149)150)117(206)160-70(5)113(202)173-93(65-185)125(214)167-89(57-100(144)191)116(205)159-64-107(200)201)177-123(212)91(60-106(198)199)168-126(215)95(67-228)175-130(219)99-37-25-52-184(99)138(227)112(73(8)189)176-104(195)63-158-127(216)96-34-22-49-181(96)135(224)85(33-21-48-155-141(151)152)166-129(218)98-36-24-51-183(98)137(226)92(59-102(146)193)172-119(208)84(42-43-105(196)197)164-128(217)97-35-23-50-182(97)136(225)86(44-53-229-9)165-120(209)88(56-76-61-156-80-29-16-15-28-78(76)80)170-132(221)109(69(4)11-2)178-134(223)111(72(7)188)179-114(203)79(143)54-75-38-40-77(190)41-39-75;3-2(4,5)1(6)7/h12-16,26-29,38-41,61,68-73,79,81-99,108-112,156,185-190,228H,10-11,17-25,30-37,42-60,62-67,142-143H2,1-9H3,(H2,144,191)(H2,145,192)(H2,146,193)(H,157,204)(H,158,216)(H,159,205)(H,160,206)(H,161,194)(H,162,213)(H,163,207)(H,164,217)(H,165,209)(H,166,218)(H,167,214)(H,168,215)(H,169,220)(H,170,221)(H,171,222)(H,172,208)(H,173,202)(H,174,210)(H,175,219)(H,176,195)(H,177,212)(H,178,223)(H,179,203)(H,180,211)(H,196,197)(H,198,199)(H,200,201)(H4,147,148,153)(H4,149,150,154)(H4,151,152,155);(H,6,7)/t68-,69-,70-,71+,72+,73+,79-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-,112-;/m0./s1
InChi Key
DLLXHIRYQVJIQN-HHCNHDPZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Rabies virus glycoprotein (RVG) peptide is a nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 2.5 µM for the human receptor).1 Lipid nanoparticles (LNPs) conjugated to RVG peptide selectively traffic to the brain over the lungs and liver in rats.2 LNPs conjugated to RVG peptide and encapsulating the iron chelator and prolyl hydroxylase inhibitor deferoxamine (DFO; Item No. 14595) reduce iron levels in the striatum and substantia nigra, as well as decrease levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and increase levels of superoxide dismutase (SOD) in the substantia nigra in a mouse model of MPTP-induced Parkinson's disease. RVG-containing and DFO-encapsulating LNPs also increase the latency to fall in the rotarod test in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lentz, T.L., Hawrot, E., and Wilson, P.T. Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptor. Proteins 2(4), 298-307 (1987).

    2. You, L., Wang, J., Liu, T., et al. Correction to targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in Parkinsonian mice. ACS Nano 16(11), 19605 (2022).