A prodrug form of C-82
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Active Metabolite(s)
42038C-82
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PRI-724

Item No. 41728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6S,9S,9aS)-hexahydro-2,9-dimethyl-4,7-dioxo-N-(phenylmethyl)-6-[[4-(phosphonooxy)phenyl]methyl]-8-(8-quinolinylmethyl)-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
CAS Number
1422253-38-0
Molecular Formula
C33H35N6O7P
Formula Weight
658.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
[H][C@]1(N(C(NCC2=CC=CC=C2)=O)N(C)CC(N1[C@H]3CC4=CC=C(OP(O)(O)=O)C=C4)=O)[C@H](C)N(CC5=CC=CC6=C5N=CC=C6)C3=O
InChi Code
InChI=1S/C33H35N6O7P/c1-22-31-38(29(40)21-36(2)39(31)33(42)35-19-24-8-4-3-5-9-24)28(18-23-13-15-27(16-14-23)46-47(43,44)45)32(41)37(22)20-26-11-6-10-25-12-7-17-34-30(25)26/h3-17,22,28,31H,18-21H2,1-2H3,(H,35,42)(H2,43,44,45)/t22-,28-,31-/m0/s1
InChi Key
VHOZWHQPEJGPCC-AZXNYEMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $61

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    10 mg

    $109

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    25 mg

    $258

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    50 mg

    $484

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    Product Description

    PRI-724 is a prodrug form of the β-catenin/CREB-binding protein (CBP) inhibitor C-82 and a derivative of ICG-001 (Item No. 16257).1 It is cytotoxic to GES-1 gastric mucosal and HGC-27, MKN45, and AGS gastric cancer cells (IC50s = 16.53, 9.8, 44.28, and 3.48 µM, respectively) and enhances decreases in viability induced by lonidamine (Item No. 14640) or 2-deoxy-D-glucose (2-DG; Item No. 14325) in CAL 27, SCC-25, and BICR 22 tongue squamous carcinoma cells.2,3 PRI-724 (0.4 mg/animal) reduces hepatic fibrosis in a mouse model of liver fibrosis induced by carbon tetrachloride (CCl4).1 It reduces the proliferation of CD4+ or CD8+ stem cell memory and central memory T cells in a rhesus macaque model of antiretroviral therapy-suppressed simian immunodeficiency virus (SIV) infection when administered at doses of 10 or 20 mg/kg per day.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Osawa, Y., Oboki, K., Imamura, J., et al. Inhibition of cyclic adenosine monophosphate (cAMP)-response element-binding protein (CREB)-binding protein (CBP)/β-catenin reduces liver fibrosis in mice. EBioMedicine 2(11), 1751-1758 (2015).

    2. Yu, Z., Jiang, X., Qin, L., et al. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Oncogene 40(5), 1027-1042 (2021).

    3. Kleszcz, R., and Paluszczak, J. The Wnt signaling pathway inhibitors improve the therapeutic activity of glycolysis modulators against tongue cancer cells. Int. J. Mol. Sci. 23(3), 1248 (2022).

    4. Mavigner, M., Zanoni, M., Tharp, G.K., et al. Pharmacological modulation of the Wnt/β-catenin pathway inhibits proliferation and promotes differentiation of long-lived memory CD4+ T cells in antiretroviral therapy-suppressed simian immunodeficiency virus-infected macaques. J. Virol. 94(1), e01094-01019 (2019).