A free radical scavenger and an inhibitor of ferroptosis
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Ferroptosis Inhibitor D1

Item No. 41822

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-cyclohexyl-5-(2-methyl-2H-tetrazol-5-yl)benzene-1,2-diamine
Molecular Formula
C14H20N6
Formula Weight
272.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
NC1=C(NC2CCCCC2)C=C(C3=NN(C)N=N3)C=C1
InChi Code
InChI=1S/C14H20N6/c1-20-18-14(17-19-20)10-7-8-12(15)13(9-10)16-11-5-3-2-4-6-11/h7-9,11,16H,2-6,15H2,1H3
InChi Key
MDHPCPBSKCGAHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $104

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    10 mg

    $192

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    25 mg

    $400

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    Product Description

    Ferroptosis inhibitor D1 is a free radical scavenger and an inhibitor of ferroptosis.1 It scavenges 41.27% of DPPH (Item No. 14805) radicals in a cell-free assay when used at a concentration of 0.4 µM. Ferroptosis inhibitor D1 (0.5 µM) inhibits lipid peroxidation induced by the ferroptosis inducer erastin (Item No. 17754) in HT-1080 cells and inhibits erastin-induced ferroptosis in the same cells (IC50 = 22 nM). In vivo, ferroptosis inhibitor D1 (5 mg/kg) reduces infarct volume and improves neurological deficits in a mouse model of ischemic brain injury induced by transient middle cerebral artery occlusion (MCAO).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, Y., Shen, Z., Xu, Y., et al. Discovery of new phenyltetrazolium derivatives as ferroptosis inhibitors for treating ischemic stroke: An example development from free radical scavengers. J. Med. Chem. 67(14), 11712-11731 (2024).