A PEGylated and biotinylated form of DPSE
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DSPE-PEG(2000)-Biotin

Item No. 41914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]-poly(oxy-1,2-ethanediyl)
Synonyms
  • 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000-Biotin
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-Polyethylene Glycol-2000-Biotin
  • DSPE-PEG2000-Biotin
  • 1,2-DSPE-PEG(2000)-Biotin
Molecular Formula
(C2H4O)nC55H100N4O12PS
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC(OC[C@H](COP(O)(OCCNC(COCCOCCNC(CCCC[C@H]1[C@]2(NC(N[C@@](CS1)2[H])=O)[H])=O)=O)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O
InChi Code
InChI=1S/C57H107N4O13PS/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-37-54(64)71-45-49(74-55(65)38-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)46-73-75(67,68)72-42-40-59-53(63)47-70-44-43-69-41-39-58-52(62)36-34-33-35-51-56-50(48-76-51)60-57(66)61-56/h49-51,56H,3-48H2,1-2H3,(H,58,62)(H,59,63)(H,67,68)(H2,60,61,66)/t49-,50+,51+,56+/m1/s1
InChi Key
SICSBOMFNKNPMX-IMFUWDGPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $108

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    10 mg

    $205

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    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
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    Product Description

    DSPE-PEG(2000)-biotin is a PEGylated and biotinylated form of 1,2-distearoyl-sn-glycero-3-PE (Item No. 15095).1,2 It has been used in the generation of liposomes for the delivery of small molecules in vitro and in vivo and for fluorescently labeling nanostructured lipid carriers (NLCs). DSPE-PEG(2000)-biotin has also been used in the formation of micelles as a precursor to immobilized liposomes for biolayer interferometry binding assays.3 Liposomes containing DSPE-PEG(2000)-biotin and encapsulating doxorubicin (Item No. 15007) and quercetin (Item No. 10005169) are cytotoxic to MCF-7/adr multidrug-resistant breast cancer cells in vitro and reduce tumor growth in an MCF-7/adr mouse xenograft model.1 NLCs containing DSPE-PEG(2000)-biotin have been fluorescently labeled using avidin-conjugated FITC.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, J., Luo, Y., Zhao, X., et al. Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG2000–DSPE modified liposomes for the treatment of multidrug resistant breast cancer. RSC Adv. 6(114), 113173–113184 (2016).

    2. Liu, D., Liu, F., Liu, Z., et al. Tumor specific delivery and therapy by double-targeted nanostructured lipid carriers with anti-VEGFR-2 antibody. Mol. Pharm. 8(6), 2291-2301 (2011).

    3. Wallner, J., Lhota, G., Schosserer, M., et al. An approach for liposome immobilization using sterically stabilized micelles (SSMs) as a precursor for bio-layer interferometry-based interaction studies. Colloids Surf B Biointerfaces 154, 186-194 (2017).