An mRNA for the expression of EPO
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EPO mRNA (Cap-1; ψUTP)

Item No. 41961

Product Insert (PDF)
Technical Information
Formulation
1 mM Sodium citrate, pH 6.4
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $208

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    $1,040

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    Cayman Chemical
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    Product Description

    EPO mRNA (Cap-1; ψUTP) encodes erythropoietin (EPO), a glycoprotein necessary for red blood cell production.1 It is capped using a co-transcriptional capping method, resulting in the naturally occurring Cap1 structure with high capping efficiency. EPO mRNA is also polyadenylated and modified with ΨUTP to reduce the host cell immune response and enhance mRNA stability. Encapsulation of EPO mRNA (Cap-1; ψUTP) in lipid nanoparticles (LNPs) can be used for mRNA delivery and expression of EPO in vitro or in vivo.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bunn, F.H. Erythropoietin. Cold Spring Harb. Perspect. Med. 3(3), a011619 (2024).

    2. Maugeri, M., Nawaz, M., Papadimitriou, A., et al. Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells. Nat. Commun. 10(1), 4333 (2019).

    3. Hajj, K.A., Melamed, J.R., Chaudhary, N., et al. A potent branched-tail lipid nanoparticle enables multiplexed mRNA delivery and gene editing in vivo. Nano Lett. 20(7), 5167-5175 (2020).