A BRM and BRG1 inhibitor
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FHT-2344

Item No. 42043

Technical Information
Formal Name
N-[(1S)-1-(methoxymethyl)-2-[[4-[3-(1-methyl-1H-pyrazol-3-yl)phenyl]-2-thiazolyl]amino]-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide
CAS Number
2468058-90-2
Molecular Formula
C23H24N6O5S2
Formula Weight
Purity
≥98%
Formulation
A solid
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CN(S(C)(=O)=O)C=C1)N[C@@H](COC)C(NC2=NC(C3=CC(C4=NN(C)C=C4)=CC=C3)=CS2)=O
InChi Code
InChI=1S/C23H24N6O5S2/c1-28-9-8-18(27-28)15-5-4-6-16(11-15)20-14-35-23(25-20)26-22(31)19(13-34-2)24-21(30)17-7-10-29(12-17)36(3,32)33/h4-12,14,19H,13H2,1-3H3,(H,24,30)(H,25,26,31)/t19-/m0/s1
InChi Key
APLVGTKXOIMODQ-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    FHT-2344 is an inhibitor of Brahma homolog (BRM), also known as SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2), and Brahma-related gene 1 (BRG1), also known as SMARCA4 (IC50s = ≥0.01 µM for both).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vaswani, R.G., Anthony, N.G., Millan, D.S., et alCompounds and uses thereof. (2020).