A BET BD2 inhibitor
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GSK973

Item No. 42057

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3S)-2-(fluoromethyl)-2,3-dihydro-N7-methyl-N5-(1α,5β,6β)-3-oxabicyclo[3.1.0]hex-6-yl-3-phenyl-5,7-benzofurandicarboxamide
CAS Number
2138473-38-6
Molecular Formula
C23H23FN2O4
Formula Weight
410.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C(C=C1[C@@H]2C3=CC=CC=C3)=CC(C(NC)=O)=C1O[C@@H]2CF)N[C@@H]4[C@]5(COC[C@]54[H])[H]
InChi Code
InChI=1S/C23H23FN2O4/c1-25-23(28)15-8-13(22(27)26-20-16-10-29-11-17(16)20)7-14-19(12-5-3-2-4-6-12)18(9-24)30-21(14)15/h2-8,16-20H,9-11H2,1H3,(H,25,28)(H,26,27)/t16-,17+,18-,19+,20+/m1/s1
InChi Key
WZQLVEPIBAOOGF-RMMWZPCPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $175

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    10 mg

    $315

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    25 mg

    $700

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    50 mg

    $1,225

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    Product Description

    GSK620 is a bromodomain and extra terminal domain family of proteins (BET) bromodomain 2 (BD2) inhibitor (IC50s = 31.62, 15.85, 15.85, and 39.81 nM for BRD2, BRD3, BRD4, and BRDTBD2, respectively).1 It is selective for BD2 in bromodomain-containing protein 2 (BRD2), BRD3, BRD4, and BRDT over BD1 in the same BRDs (IC50s = >10,000 nM for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Preston, A., Atkinson, S.J., Bamborough, P., et al. GSK973 Is an inhibitor of the second bromodomains (BD2s) of the bromodomain and extra-terminal (BET) family. ACS Med. Chem. Lett. 11(8), 1581-1587 (2020).