A GSK3β inhibitor
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GSK3β Inhibitor 1

Item No. 42107

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z)-1,3-dihydro-3-(2-pyridinylmethylene)-2H-indol-2-one
CAS Number
187325-53-7
Synonyms
  • Glycogen Synthase Kinase 3β Inhibitor I
Molecular Formula
C14H10N2O
Formula Weight
222.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NC1=CC=CC=C1/2)C2=C/C3=CC=CC=N3
InChi Code
InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
InChi Key
YKQONSWBHGBDSB-XFXZXTDPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $160

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    10 mg

    $288

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    25 mg

    $638

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    50 mg

    $957

    Add
    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    GSK3β inhibitor 1 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 4.19 nM).1 In vivo, GSK3β inhibitor 1 (50 mg/kg) decreases blood glucose levels in an oral glucose tolerance test (OGTT) in a rat model of diabetes induced by a high-fat diet and streptozotocin (STZ; Item No. 13104).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lozinskaya, N.A., Babkov, D.A., Zaryanova, E.V., et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg. Med. Chem. 27(9), 1804-1817 (2019).