A RIPK2 inhibitor
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RIPK2 Inhibitor OD36 (hydrochloride)

Item No. 42171

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(13Z)-25-chloro-14,15-dihydro-3,6-dioxa-9-aza-1(3,5)-pyrazolo[1,5-a]pyrimidina-2(1,3)-benzenacyclononaphane, monohydrochloride
CAS Number
2387510-88-3
Synonyms
  • OD36
  • Receptor-interacting Serine/Threonine Kinase 2 Inhibitor OD36
Molecular Formula
C16H15ClN4O2 • HCl
Formula Weight
367.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
ClC1=CC2=CC(C3=C4N(C=CC(N4)=NCCOCCO2)N=C3)=C1.Cl
InChi Code
InChI=1S/C16H15ClN4O2.ClH/c17-12-7-11-8-13(9-12)23-6-5-22-4-2-18-15-1-3-21-16(20-15)14(11)10-19-21;/h1,3,7-10H,2,4-6H2,(H,18,20);1H
InChi Key
VGOJZWODJXQKMN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    RIPK2 inhibitor OD36 is an inhibitor of receptor-interacting serine/threonine kinase 2 (RIPK2; IC50 = 5.3 nM).1 It also inhibits wild-type and R206H mutant activin receptor-like kinase 2 (ALK2; IC50s = 47 and 22 nM, respectively).2 RIPK2 inhibitor OD36 (0.5 µM) inhibits activin A-induced chondrogenic and osteogenic differentiation in ATDC-5 cells overexpressing ALKR206H, an activating mutation found in patients with fibrodysplasia ossificans progressiva (FOP), which is characterized by progressive heterotopic ossification, or diffuse intrinsic pontine glioma (DIPG), a type of pediatric brain stem cancer. In vivo, RIPK2 inhibitor OD36 (6.25 mg/kg) reduces the number of peritoneal lavage neutrophils and lymphocytes in a mouse model of muramyl dipeptide-induced peritonitis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tigno-Aranjuez, J.T., Benderitter, P., Rombouts, F., et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. The Journal of Biological Chemisty 289(43), 29651-29664 (2014).

    2. Sánchez-Duffhues, G., Williams, E., Benderitter, P., et al. Development of macrocycle kinase inhibitors for ALK2 using fibrodysplasia ossificans progressiva-derived endothelial cells. JBMR Plus 3(11), e10230 (2019).