A prenylated quinolinecarboxylic acid with diverse biological activities
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Ppc-1

Item No. 42352

Product Insert (PDF)
Technical Information
Formal Name
4-methoxy-8-[(3-methyl-2-buten-1-yl)oxy]-2-quinolinecarboxylic acid, 3-methyl-2-buten-1-yl ester
CAS Number
1245818-17-0
Molecular Formula
C21H25NO4
Formula Weight
355.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
COC1=C(C=CC=C2OC/C=C(C)\C)C2=NC(C(OC/C=C(C)/C)=O)=C1
InChi Code
InChI=1S/C21H25NO4/c1-14(2)9-11-25-18-8-6-7-16-19(24-5)13-17(22-20(16)18)21(23)26-12-10-15(3)4/h6-10,13H,11-12H2,1-5H3
InChi Key
PBLQSFOIWOTFNY-UHFFFAOYSA-N
Origin
Fungus/P. pseudo-candidum
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $468

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ppc-1 is a prenylated quinolinecarboxylic acid originally isolated from P. pseudo-candidum that has diverse biological activities.1,2,3 It reduces the proliferation of K562 chronic myelogenous leukemia (CML) cells and 3T3-L1 mouse fibroblasts when used at a concentration of 15 µM.1 Ppc-1 (1 and 10 µM) inhibits the production of IL-2 induced by concanavalin A (Item No. 14951) in Jurkat T cells.2 In vivo, Ppc-1 (0.8 mg/kg) reduces body weight gain and increases serum fatty acid levels in mice fed a commercial diet.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kikuchi, H., Nakamura, K., Kubohara, Y., et al. Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66(32), 6000-6007 (2010).

    2. Ogura, M., Kikuchi, H., Suzuki, T., et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 105, 55-65 (2016).

    3. Suzuki, T., Kikuchi, H., Ogura, M., et al. Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. PLoS One 10(2), e0117088 (2015).