A phenolic glycoside with diverse biological activities
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Orcinol Glucoside

Item No. 42365

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-5-methylphenyl β-D-glucopyranoside
CAS Number
21082-33-7
Synonyms
  • Sakakin
Molecular Formula
C13H18O7
Formula Weight
286.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
OC[C@H]1O[C@@H](OC2=CC(C)=CC(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChi Code
InChI=1S/C13H18O7/c1-6-2-7(15)4-8(3-6)19-13-12(18)11(17)10(16)9(5-14)20-13/h2-4,9-18H,5H2,1H3/t9-,10-,11+,12-,13-/m1/s1
InChi Key
YTXIGTCAQNODGD-UJPOAAIJSA-N
Origin
Plant/Curculigo orchioides Gaertn.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $55

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    10 mg

    $83

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    25 mg

    $172

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    Product Description

    Orcinol glucoside is a phenolic glycoside that has been found in C. orchioides and has diverse biological activities.1,2,3,4 It scavenges hydrogen peroxide- and iron-induced hydroxyl- and superoxide anion radicals in cell-free assays (IC50s = 1.39 and 2.49 mM, respectively).1 Orcinol glucoside (100 nM) increases proliferation, alkaline phosphatase (Alp) activity, and levels of collagen I and Runx family transcription factor 2 (Runx2) in primary mouse osteoblasts.2 It prevents dexamethasone-induced decreases in femur bone mass density and volume in mice when administered at a dose of 20 mg/kg per day. Orcinol glucoside (1.5, 3, or 6 mg/kg) reduces immobility time in the forced swim test and serum levels of corticosterone in a rat model of chronic unpredictable stress-induced depression.3 It increases the number of entries into and time spent in the open arms of the elevated plus maze in mice when administered at doses of 5, 10, or 20 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, Q., Fu, D.-X., Hou, A.-J., et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem. Pharm. Bull. (Tokyo) 53(8), 1065-1067 (2005).

    2. He, X.-Y.-X., Zhao, W.-L., Yao, L.-P., et al. Orcinol glucoside targeted p38 as an agonist to promote osteogenesis and protect glucocorticoid-induced osteoporosis. Phytomedicine 119, 154953 (2023).

    3. Ge, J.-F., Gao, W.-C., Cheng, W.-M., et al. Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress. Eur. Neuropsychopharmacol. 24(1), 172-180 (2014).

    4. Wang, X., Li, G., Li, P., et al. Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice. Pharm. Biol. 53(6), 876-881 (2015).