A phenolic glycoside with diverse biological activities
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Isomer(s)
42365Orcinol Glucoside
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Gastrodin

Item No. 28828

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(hydroxymethyl)phenyl β-D-glucopyranoside
CAS Number
62499-27-8
Molecular Formula
C13H18O7
Formula Weight
286.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
223 nm
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(CO)C=C2)O1
InChi Code
InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1
InChi Key
PUQSUZTXKPLAPR-UJPOAAIJSA-N
Origin
Plant/Gastrodia elata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $107

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    100 mg

    $203

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    250 mg

    $477

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    500 mg

    $898

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    Product Description

    Gastrodin is a phenolic glycoside that has been found in Gastrodia and has diverse biological activities.1,2,3,4 It reduces cell death of rat hippocampal neurons and BV-2 mouse microglia induced by amyloid-β (1-42) (Aβ42; Item No. 20574) and improves learning and memory in various transgenic mouse models of Alzheimer's disease.1 It reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330). Gastrodin (50-200 mg/kg) reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures. In a mouse model of valproic acid-induced autistic-like phenotypes, gastrodin (100 mg/kg) increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and α5 subunit-containing GABAA expression in the basolateral amygdala.2 Gastrodin increases ultimate breaking force and bone stiffness, measures of biomechanical strength, in a rat model of osteoporosis induced by dexamethasone (Item No. 11015).3 It also inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y., Gao, J., Peng, M., et al. A review on central nervous system effects of gastrodin. Front. Pharmacol. 9:24, (2018).

    2. Wang, X., Tao, J., Qiao, Y., et al. Gastrodin rescues autistic-like phenotypes in valproic acid-induced animal model. Front. Neurol. 9:1052, (2018).

    3. Liu, S., Zhou, L., Yang, L., et al. Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways. Oncotarget 9(14), 11528-11540 (2018).

    4. Zhang, Y., Wang, C., Yu, B., et al. Gastrodin protects against ethanol-induced liver injury and apoptosis in HepG2 cells and animal models of alcoholic liver disease. Biol. Pharm. Bull. 41(5), 670-679 (2018).