A peptide antagonist of GAL2 receptors
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M871 (trifluoroacetate salt)

Item No. 42403

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-α-glutamyl-L-histidyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-alaninamide, trifluoroacetate salt
Molecular Formula
C108H163N27O28 • XCF3COOH
Formula Weight
2287.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
WXLNSAGYLLGPEHPPPALALA-NH2 (X = ξ-threonine)
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly Soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml
SMILES
[H]N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N1CCC[C@H]1C(N[C@@H](CCC(O)=O)C(N[C@H](C(N2CCC[C@H]2C(N3CCC[C@H]3C(N4CCC[C@H]4C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)C)=O)=O)C)=O)=O)C)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)C)=O)=O)=O)=O)=O)CC7=CNC8=C7C=CC=C8.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C108H163N27O28.C2HF3O2/c1-53(2)38-71(125-98(153)74(41-56(7)8)126-100(155)76(43-63-28-30-66(138)31-29-63)121-85(140)49-114-90(145)59(12)118-102(157)79(51-136)130-101(156)77(46-84(110)139)127-99(154)75(42-57(9)10)128-105(160)88(62(15)137)131-93(148)68(109)44-64-47-113-69-23-17-16-22-67(64)69)94(149)115-50-86(141)132-34-18-24-80(132)104(159)122-70(32-33-87(142)143)95(150)129-78(45-65-48-112-52-116-65)106(161)134-36-20-26-82(134)108(163)135-37-21-27-83(135)107(162)133-35-19-25-81(133)103(158)120-61(14)92(147)124-73(40-55(5)6)97(152)119-60(13)91(146)123-72(39-54(3)4)96(151)117-58(11)89(111)144;3-2(4,5)1(6)7/h16-17,22-23,28-31,47-48,52-62,68,70-83,88,113,136-138H,18-21,24-27,32-46,49-51,109H2,1-15H3,(H2,110,139)(H2,111,144)(H,112,116)(H,114,145)(H,115,149)(H,117,151)(H,118,157)(H,119,152)(H,120,158)(H,121,140)(H,122,159)(H,123,146)(H,124,147)(H,125,153)(H,126,155)(H,127,154)(H,128,160)(H,129,150)(H,130,156)(H,131,148)(H,142,143);(H,6,7)/t58-,59-,60-,61-,62+,68-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,88-;/m0./s1
InChi Key
OJUCWDYWVHRMSI-KFLBMCOOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

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    10 mg

    $620

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    M871 is a peptide antagonist of galanin-2 (GAL2) receptors (Ki = 13.1 nM).1 It is selective for GAL2 receptors over GAL1 receptors (Ki = 420 nM). M871 (0.1, 1, or 10 nM) inhibits galanin-induced increases in inositol levels in CHO cells expressing human GAL2 receptors. It increases blood glucose, IL-8, IL-6, IL-22, and Tnf-α levels and decreases skeletal muscle and adipocyte glucose transporter 4 (Glut4) and peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc-1α) levels in a rat model of diabetes induced by a high-fat diet and streptozotocin (STZ; Item No. 13104) when administered intracerebroventricularly.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sollenberg, U., Lundström, L., Bartfai, T., et al. M871—a novel peptide antagonist selectively recognizing the galanin receptor type 2. Int. J. Pept. Res. Ther. 12, 115–119 (2006).

    2. Fang, P., He, B., Yu, M., et al. Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats. Biochem. Pharmacol. 156, 241-247 (2018).