A DPP-4 inhibitor
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K579

Item No. 42505

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2S-[[4-methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
CAS Number
440100-64-1
Molecular Formula
C17H24N6O
Formula Weight
328.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N1CCC[C@H]1C#N)CNC2(CCN(C3=NC=CC=N3)CC2)C
InChi Code
InChI=1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
InChi Key
JERPHRNGJBSFAP-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $212

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    10 mg

    $358

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    K579 is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 5 nM for the human enzyme).1 In vivo, K579 (1 mg/kg) reduces plasma DPP-4 activity and glucose levels and increases plasma insulin levels in an oral glucose tolerance test (OGTT) in wild-type and fa/fa Zucker fatty rats. It also reduces total ulcer length in a rat model of intestinal ulcers induced by indomethacin (Item No. 70270).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takasaki, K., Iwase, M., Nakajima, T., et al. K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. Eur. J. Pharmacol. 486(3), 335-342 (2004).

    2. Inoue, T., Higashiyama, M., Kaji, I., et al. Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. Dig. Dis. Sci. 59(6), 1286-1295 (2014).