An internal standard for the quantification of homosalate
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Unlabeled Version(s)
42720Homosalate
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Homosalate-d4

Item No. 42536

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3,5-trimethylcyclohexyl 2-hydroxybenzoate-3,4,5,6-d4
Molecular Formula
C16H18D4O3
Formula Weight
266.4
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly Soluble: 1-10mg/mLMethyl Acetate: Sparingly Soluble: 1-10mg/mL
SMILES
OC1=C([2H])C([2H])=C([2H])C([2H])=C1C(OC2CC(C)CC(C)(C)C2)=O
InChi Code
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3/i4D,5D,6D,7D
InChi Key
WSSJONWNBBTCMG-UGWFXTGHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    500 µg

    $109

    Add

    1 mg

    $164

    Add
    Product Description

    Homosalate-d4 is intended for use as an internal standard for the quantification of homosalate by GC- or LC-MS. Homosalate is a filter for UVB radiation.1 It reduces ear edema induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) by 82.5 and 70% before and after UV irradiation, respectively, in mice.2 Homosalate has androgenic and antiandrogenic activities in reporter assays using S. cerevisiae expressing the human androgen receptor (EC50s = 170 and 107 µM, respectively).3 It also has anti-estrogenic activity in a reporter assay using S. cerevisiae expressing human estrogen receptor α (ERα; EC50 = 2,060 µM). Formulations containing homosalate have been used as sun protectants in sunscreen products.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holt, E.L., Krokidi, K.M., Turner, M.A.P., et al. Insights into the photoprotection mechanism of the UV filter homosalate. Phys. Chem. Chem. Phys. 22(27), 15509-15519 (2020).

    2. Couteau, C., Couteau, O., Chauvet, C., et al. The effect of ultraviolet radiation on the anti-inflammatory effect of filters. Int. J. Pharm. 452(1-2), 124-127 (2013).

    3. Kunz, P.Y., and Fent, K. Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat. Toxicol. 79(4), 305-324 (2006).