A filter for UVB radiation
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Labeled Version(s)
42536Homosalate-d4
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Homosalate

Item No. 42720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-benzoic acid, 3,3,5-trimethylcyclohexyl ester
CAS Number
118-56-9
Synonyms
  • NSC 164918
Molecular Formula
C16H22O3
Formula Weight
262.3
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(OC1CC(C)CC(C)(C)C1)C2=C(O)C=CC=C2
InChi Code
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3
InChi Key
WSSJONWNBBTCMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 g

    $72

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    5 g

    $161

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    10 g

    $251

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    Product Description

    Homosalate is a filter for UVB radiation.1 It reduces ear edema induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) by 82.5 and 70% before and after UV irradiation, respectively, in mice.2 Homosalate has androgenic and antiandrogenic activities in reporter assays using S. cerevisiae expressing the human androgen receptor (EC50s = 170 and 107 µM, respectively).3 It also has anti-estrogenic activity in a reporter assay using S. cerevisiae expressing human estrogen receptor α (ERα; EC50 = 2,060 µM). Formulations containing homosalate have been used as sun protectants in sunscreen products.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holt, E.L., Krokidi, K.M., Turner, M.A.P., et al. Insights into the photoprotection mechanism of the UV filter homosalate. Phys. Chem. Chem. Phys. 22(27), 15509-15519 (2020).

    2. Couteau, C., Couteau, O., Chauvet, C., et al. The effect of ultraviolet radiation on the anti-inflammatory effect of filters. Int. J. Pharm. 452(1-2), 124-127 (2013).

    3. Kunz, P.Y., and Fent, K. Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat. Toxicol. 79(4), 305-324 (2006).