A filter for UVB radiation
Related Products
Labeled Version(s)
42536Homosalate-d4
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Homosalate

Item No. 42720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-benzoic acid, 3,3,5-trimethylcyclohexyl ester
CAS Number
118-56-9
Synonyms
  • NSC 164918
Molecular Formula
C16H22O3
Formula Weight
262.3
Purity
≥95% (mixture of diastereomers)
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(OC1CC(C)CC(C)(C)C1)C2=C(O)C=CC=C2
InChi Code
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3
InChi Key
WSSJONWNBBTCMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 g

    $72

    Add

    5 g

    $161

    Add

    10 g

    $251

    Add
    Product Description

    Homosalate is a filter for UVB radiation.1 It reduces ear edema induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) by 82.5 and 70% before and after UV irradiation, respectively, in mice.2 Homosalate has androgenic and antiandrogenic activities in reporter assays using S. cerevisiae expressing the human androgen receptor (EC50s = 170 and 107 µM, respectively).3 It also has anti-estrogenic activity in a reporter assay using S. cerevisiae expressing human estrogen receptor α (ERα; EC50 = 2,060 µM). Formulations containing homosalate have been used as sun protectants in sunscreen products.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holt, E.L., Krokidi, K.M., Turner, M.A.P., et al. Insights into the photoprotection mechanism of the UV filter homosalate. Phys. Chem. Chem. Phys. 22(27), 15509-15519 (2020).

    2. Couteau, C., Couteau, O., Chauvet, C., et al. The effect of ultraviolet radiation on the anti-inflammatory effect of filters. Int. J. Pharm. 452(1-2), 124-127 (2013).

    3. Kunz, P.Y., and Fent, K. Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat. Toxicol. 79(4), 305-324 (2006).