A synthetic pentacyclic triterpenoid
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Corosolic Acid β

Item No. 42738

Product Insert (PDF)
Technical Information
Formal Name
2α,3β-dihydroxy-urs-12-en-28-oic acid, propyl ester
CAS Number
958237-73-5
Synonyms
  • CAβ
Molecular Formula
C33H54O4
Formula Weight
514.8
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: Soluble: ≥10 mg/ml
SMILES
O[C@H]1[C@@H](C(C)([C@@]([H])([C@@]2(C1)C)CC[C@@]3([C@@]2(CC=C4[C@]3(CC[C@@]5([C@]4([C@H]([C@@H](CC5)C)C)[H])C(OCCC)=O)C)[H])C)C)O
InChi Code
InChI=1S/C33H54O4/c1-9-18-37-28(36)33-15-12-20(2)21(3)26(33)22-10-11-25-30(6)19-23(34)27(35)29(4,5)24(30)13-14-32(25,8)31(22,7)16-17-33/h10,20-21,23-27,34-35H,9,11-19H2,1-8H3/t20-,21+,23-,24+,25-,26+,27+,30+,31-,32-,33+/m1/s1
InChi Key
PKWCYQYJRALNAD-IHYXPCQHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $382

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    10 mg

    $545

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    Cayman Chemical
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    Product Description

    Corosolic acid β is a synthetic pentacyclic triterpenoid and derivative of corosolic acid (Item No. 27887) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vitro and in vivo.1 It also inhibits glycogen phosphorylase (IC50 = 82.5 µM for the rabbit muscle enzyme).2 LNPs containing corosolic acid β and encapsulating an mRNA reporter show greater transfection efficiency than those containing cholesterol (Item Nos. 9003100 | 39088) in 4T1, B16/F10, and HeLa cells.1 Corosolic acid β-containing LNPs selectively accumulate in tumors and do not accumulate in the liver compared with cholesterol-containing LNPs, which accumulate in both, following intratumoral injection. LNPs containing corosolic acid β and encapsulating siRNA targeting mRNA encoding Bcl-2 decrease tumor volume and lung metastasis and increase survival in a 4T1 murine mammary carcinoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y., Zhang, R., Yang, Y., et al. Corosolic acid derivative-based lipid nanoparticles for efficient RNA delivery. J. Control. Release 378, 1-17 (2024).

    2. Wen, X., Xia, J., Cheng, K., et al. Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases. Bioorg. Med. Chem. Lett. 17(21), 5777-5782 (2007).