A neurokinin A derivative and fragment of EB1001
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[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (trifluoroacetate salt)

Item No. 42740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,6S,9S,12S,18S,21S)-3-amino-6-(4-aminobutyl)-21-hydrazineyl-9-(4-hydroxybenzyl)-18-isobutyl-12-isopropyl-19-methyl-4,7,10,13,16,17,20-heptaoxo-5,8,11,14,19-pentaazapentacosanoic acid, trifluoroacetate salt
Synonyms
  • Neurokinin A (4-10)-S5K/F6Y/L9mL/M10Nle
  • [Lys5,Tyr6,mLeu9,Nle10]-NKA (4-10)
Molecular Formula
C39H65N9O10 • XCF3COOH
Formula Weight
820.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
DKYVGmLNle-NH2
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlWater: Sparingly Soluble: 1-10 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N(C)[C@H](C(N[C@H](C(N)=O)CCCC)=O)CC(C)C)=O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)CC(O)=O
InChi Code
InChI=1S/C39H65N9O10.C2HF3O2/c1-7-8-11-27(34(42)53)44-38(57)30(18-22(2)3)48(6)31(50)21-43-39(58)33(23(4)5)47-37(56)29(19-24-13-15-25(49)16-14-24)46-36(55)28(12-9-10-17-40)45-35(54)26(41)20-32(51)52;3-2(4,5)1(6)7/h13-16,22-23,26-30,33,49H,7-12,17-21,40-41H2,1-6H3,(H2,42,53)(H,43,58)(H,44,57)(H,45,54)(H,46,55)(H,47,56)(H,51,52);(H,6,7)/t26-,27-,28-,29-,30-,33-;/m0./s1
InChi Key
TYHYPVRZALFWCJ-WVHCJTCASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $204

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    10 mg

    $387

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    25 mg

    $858

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) is a derivative of neurokinin A (Item No. 24221) containing serine-to-lysine, phenylalanine-to-tyrosine, leucine-to-methylleucine, and methionine-to-norleucine substitutions at positions 5, 6, 9, and 10, respectively, and a peptide fragment of the neurokinin-2 (NK2) receptor agonist EB1001.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sass, F., Ma, T., Ekberg, J.H., et al. NK2R control of energy expenditure and feeding to treat metabolic diseases. Nature 635(8040), 987-1000 (2024).