TGF-β2 (mouse, recombinant)

TGF-β2 is a multifunctional cytokine and member of the TGF-β superfamily.^1,2 It is a ubiquitously expressed proprotein that is cleaved in the endoplasmic reticulum to form TGF-β2 latency-associated peptide (LAP) and mature TGF-β2.² LAP and TGF-β2 remain non-covalently bound until mature TGF-β2 is released into the extracellular matrix from a latency complex by various proteins, including matrix metalloproteinases (MMPs), plasmin, and prostate-specific antigen (PSA). TGF-β2 binds to TGF-β receptor type 3 (TGFBR3), which recruits TGFBR2 and ALK5, also known as TGF-βRI, to induce canonical signaling through SMAD2/3 or non-canonical signaling through various pathways, including PI3K/Akt/mTOR, ERK1/2, or JNK. It is involved in diverse biological processes, including cell differentiation, embryonic development of the heart and motor system, immune system regulation, and glucose tolerance, as well as tumorigenesis.^2,3 Mutations in TGFB2 are associated with thoracic aortic aneurysms.⁴ Cayman’s TGF-β2 (mouse, recombinant) protein consists of 406 amino acids, has a calculated molecular weight of 46.9 kDa, and a predicted N-terminus of Ser20 after signal peptide cleavage.

WARNING This product is not for human or veterinary use.

1. Khalil, N. TGF-β: From latent to active. Microbes Infect. 1(15), 1255-1263 (1999).

2. Wang, M.-Y., Liu, W.-J., Wu, L.-Y., et al. The research progress in transforming growth factor-β₂. Cells 12(23), 2739 (2023).

3. Takahashi, H., Alves, C.R.R., Stanford, K.I., et al. TGF-β₂ is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nat. Metab. 1(2), 291-303 (2019).

4. Boileau, C., Guo, D.C., Hanna, N., et al. TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nat. Genet. 44(8), 916-921 (2012).